Bacterial plasmids are ubiquitous ‘minichromosomes’ that have major importance in clinical microbiology, as agents of pathogenicity and as carriers of antibiotic resistance, and in molecular genetics, through their role as vectors in gene manipulation. Plasmids carry a wide range of dispensable, transiently useful and often bizarre functions.1 Naturally occurring plasmids, in addition to modifying the host cell phenotype, carry genes involved in the control of their own vegetative replication, plasmid copy number2 and stable inheritance. They may also carry determinants for (...) the conjugal transfer of DNA between bacteria.3 Whereas low‐copy‐number plasmids must be partitioned by some active process during cell division, the evidence suggests that multicopy plasmids are distributed randomly between daughter cells. Two independent determinants are necessary for the stable inheritance of multicopy plasmids, and both of these appear to act by maximizing the number of independent plasmid molecules. (shrink)

For over a century, the Danish thinker Søren Kierkegaard has been at the center of a number of important discussions, concerning not only philosophy and theology, but also, more recently, fields such as social thought, psychology, and contemporary aesthetics, especially literary theory. Despite his relatively short life, Kierkegaard was an extraordinarily prolific writer, as attested to by the 26-volume Princeton University Press edition of all of his published writings. But Kierkegaard left behind nearly as much unpublished writing, most of which (...) consists of what are called his "journals and notebooks." Kierkegaard has long been recognized as one of history's great journal keepers, but only rather small portions of his journals and notebooks are what we usually understand by the term "diaries." By far the greater part of Kierkegaard's journals and notebooks consists of reflections on a myriad of subjects--philosophical, religious, political, personal. Studying his journals and notebooks takes us into his workshop, where we can see his entire universe of thought. We can witness the genesis of his published works, to be sure--but we can also see whole galaxies of concepts, new insights, and fragments, large and small, of partially completed but unpublished works. Kierkegaard's Journals and Notebooks enables us to see the thinker in dialogue with his times and with himself. Volume 5 of this 11-volume series includes five of Kierkegaard's important "NB" journals, covering the months from summer 1848 through early May 1849. This was a turbulent period both in the history of Denmark--which was experiencing the immediate aftermath of revolution and the fall of absolutism, a continuing war with the German states, and the replacement of the State Church with the Danish People's Church--and for Kierkegaard personally. The journals in the present volume include Kierkegaard's reactions to the political upheaval, a retrospective account of his audiences with King Christian VIII, deliberations about publishing an autobiographical explanation of his writings, and an increasingly harsh critique of the Danish Church. These journals also reflect Kierkegaard's deep concern over his collision with the satirical journal Corsair, an experience that helped radicalize his view of "essential Christianity" and caused him to ponder the meaning of martyrdom. Kierkegaard wrote his journals in a two-column format, one for his initial entries and the second for the extensive marginal comments that he added later. This edition of the journals reproduces this format, includes several photographs of original manuscript pages, and contains extensive scholarly commentary on the various entries and on the history of the manuscripts being reproduced. (shrink)

This book is a defense of modal realism; the thesis that our world is but one of a plurality of worlds, and that the individuals that inhabit our world are only a few out of all the inhabitants of all the worlds. Lewis argues that the philosophical utility of modal realism is a good reason for believing that it is true.

This volume is devoted to Lewis's work in ethics and social philosophy. Topics covered include the logic of obligation and permission; decision theory and its relation to the idea that beliefs might play the motivating role of desires; a subjectivist analysis of value; dilemmas in virtue ethics; the problem of evil; problems about self-prediction; social coordination, linguistic and otherwise; alleged duties to rescue distant strangers; toleration as a tacit treaty; nuclear warfare; and punishment. This collection, and the two preceding volumes, (...) will disseminate more widely the work of an eminent and influential contemporary philosopher. (shrink)

What knowledge would suffice to yield an interpretation of an arbitrary utterance of a language when such knowledge is based on evidence plausibly available to a nonspeaker of that language? it is argued that it is enough to know a theory of truth for the language and that the theory satisfies tarski's 'convention t' and that it gives an optimal fit to data about sentences held true, Under specified conditions, By native speakers.

This is the first of a three-volume collection of David Lewis's most recent papers in all the areas to which he has made significant contributions. The purpose of this collection (and the two volumes to follow) is to disseminate even more widely the work of a preeminent and influential late twentieth-century philosopher. The papers are now offered in a readily accessible format. This first volume is devoted to Lewis's work on philosophical logic from the last twenty-five years. The topics (...) covered include: deploying the methods of formal semantics from artificial formalised languages to natural languages, model-theoretic investigations of intensional logic, contradiction, relevance, the differences between analog and digital representation, and questions arising from the construction of ambitious formalised philosophical systems. The volume will serve as an important reference tool for all philosophers and their students. (shrink)

Common formulations of the principle of charity in translation seem to undermine attributions of irrationality in social scientific accounts that are otherwise unexceptionable. This I call the problem of irrationality. Here I resolve the problem of irrationality by developing two complementary views of the principle of charity. First, I develop the view (ill-developed in the literature at present) that the principle of charity is preparatory, being needed in the construction of provisional first-approximation translation manuals. These serve as the basis for (...) explanatory accounts and associated refinements in the translation manual. In developing such explanatory accounts, the principle of charity is no longer constraining. Thus, the principle of charity applies only in the early stages of constructing translation manuals, and there is no problem of irrationality in the later stages of constructing translation manuals. Second, I reduce the principle of charity, where it does apply, to a special case of what I call the principle of explicability: so translate as to attribute explicable beliefs and practices to the speakers of the source-language. I show that the appropriate formulation of the principle of charity counsels just what the principle of explicability requires in the early stages of social scientific investigation. (shrink)

David Kellogg Lewis (1941-2001) was one of the most influential philosophers of the twentieth century. He made significant contributions to almost every area of analytic philosophy including metaphysics, philosophy of language, philosophy of mind, and philosophy of science, and set the agenda for various debates in these areas which carry on to this day. In several respects he remains a contemporary figure, yet enough time has now passed for historians of philosophy to begin to study his place in twentieth (...) century thought. His philosophy was constructed and refined not just through his published writing, but also crucially through his life-long correspondence with fellow philosophers, including leading figures such as D.M. Armstrong, Saul Kripke, W.V. Quine, J.J.C. Smart, and Peter van Inwagen. His letters formed the undercurrent of his published work and became the medium through which he proposed many of his well-known theories and discussed a range of philosophical topics in depth. A selection of his vast correspondence over a 40-year period is presented here across two volumes. The letters offer an organic story of the origins, development, breadth, and depth of his philosophy in its historical context, as well as a glimpse into the influence of his many interlocutors."-- OCLC OLUC. (shrink)

Counterfactuals is David Lewis' forceful presentation of and sustained argument for a particular view about propositions which express contrary to fact conditionals, including his famous defense of realism about possible worlds and his theory of laws of nature.

Epistemic Evaluation aims to explore and apply a particular methodology in epistemology. The methodology is to consider the point or purpose of our epistemic evaluations, and to pursue epistemological theory in light of such matters. Call this purposeful epistemology. The idea is that considerations about the point and purpose of epistemic evaluation might fruitfully constrain epistemological theory and yield insights for epistemological reflection. Several contributions to this volume explicitly address this general methodology, or some version of it. Others focus on (...) advancing some application of the methodology rather than on theorizing about it. The papers go on to explore the idea that purposes allow one to understand the conceptual demands on knowing, examine how purposeful epistemology might shed light on the debate between internalist and externalist epistemologies, and further develop the idea of purposeful epistemology. (shrink)

This paper seeks to reconstruct the role of schooling in a moment of accelerated social, political, economic, geo-political, climatic, indeed planetary crisis. It identifies the school as a potentially prefigurative institution, an evolutionary social frontier, capable of nurturing the democratic social character, a form of sensibility apart from which authentic political democracy is not possible. As theorized by Herbert Marcuse and Richard Hart and Antonio Negri, the “new sensibility” or “multitude” is characterized by greater psychological freedom, individuality, social creativity and (...) self-rule, comprising a “whole of singularities” that “acts in common”. It suggests a human subject with a vital, biological drive for liberation, with a consciousness capable of breaking through the material as well as ideological veil of a society based on hierarchy and domination, and is associated politically with democracy and social-anarchism, or what Murray Bookchin called “communalism”. This paper identifies three main characteristics of an institution informed by this form of modal subjectivity, all of them based on student-teacher dialogue: an emergent, project-based curriculum, whole-school direct democratic governance on all levels of the community, and the regular practice of communal philosophical inquiry, through which we problematize the concepts we live by, in the interest of their ongoing reconstruction. (shrink)

Henderson and Horgan set out a broad new approach to epistemology. They defend the roles of the a priori and conceptual analysis, but with an essential empirical dimension. 'Transglobal reliability' is the key to epistemic justification. The question of which cognitive processes are reliable depends on contingent facts about human capacities.

D. H. Hodgson has argued that among highly knowledgeable and rational act-Utilitarians there is no non-Circular reason to be truthful or to expect truthfulness from others; wherefore these utilitarians forfeit the benefits of communication. I reply that hodgson goes wrong by tacitly assuming that his utilitarians have no premises to reason from except those that hodgson lays down in specifying the example under consideration.

Christianity teaches that whenever evil is done, God had ample warning. He could have prevented it, but He didn't. He could have stopped it midway, but He didn't. He could have rescued the victims of the evil, but - at least in many cases - He didn't. In short, God is an accessory before, during, and after the fact to countless evil deeds, great and small. An explanation is not far to seek. The obvious hypothesis is that the Christian God (...) is really some sort of devil. Maybe He is a devil as popularly conceived, driven' by malice. Or maybe He is unintelligibly capricious. Or maybe He is a fanatical artist who cares only for the aesthetic quality of creation - perhaps the abstract beauty of getting rich variety to emerge from a few simple laws, or perhaps the concrete drama of human life with all its diversity - and cares nothing for the good of the creatures whose lives are woven into His masterpiece. Oust as a tragedian has no business providing a happy end out of compassion for his characters.) But no; for Christianity also teaches that God is morally perfect and perfectly benevolent, and that He loves all of His creatures; and that these things are true in a sense not a million miles from the sense in which we attribute morality, benevolence, or love to one another. (shrink)

In his note "can there be vague objects?" ("analysis", 1978), Gareth evans presents a purported proof that there can be no vague identity statements. Some readers think that evans endorses the proof and its false conclusion. Not so. His point is that those who put vagueness in the world, Rather than in language, Will have no way to fault the proof and no way to escape the false conclusion.

Topics in Cognitive Science, Volume 13, Issue 1, Page 128-141, January 2021.

The Simple View (SV) holds that for someone to intentionally A, he must intend to A. Critics of SV point to intentional actions which, due to belief-conditions or consistency constraints, agents cannot intend. By recognizing species of intention which vary according to the agent's confidence in acting, I argue that the stringency of consistency constraints depends on the agent's confidence. A more sophisticated SV holds that the species of intending is related to the degree of intentionality of the action. Finally, (...) I show that where agents do what they believe impossible, without intending to do so, the action is not intentional. (shrink)

My paper critiques the comparability requirement that practical reason is limited by the possibility of comparing alternatives. I describe methods of reasoning that are compatible with choice between incomparable options, and discuss a mistake about intention that supports the view that comparing alternatives is the only way to choose rationally. I then explain how a model of rational choice that prescribes the comparison of alternatives invents unacceptable concepts to make comparability possible. Finally, I criticize the assumption of the unity of (...) practical reason that requires that prudential and moral choices are both made by comparing alternatives. It turns out that moral conflicts that are intractable for those who reason with a method of comparison may be resolvable by using moral reasoning that does not involve the comparison of alternatives in terms of a comprehensive value. Making room for such forms of reasoning is preferable to denying incomparability. (shrink)

is the second-order theory of the part-whole relation. It can express such hypotheses about the size of Reality as that there are inaccessibly many atoms. Take a non-empty class to have exactly its non-empty subclasses as parts; hence, its singleton subclasses as atomic parts. Then standard set theory becomes the theory of the member-singleton function—better, the theory of all singleton functions—within the framework of megethology. Given inaccessibly many atoms and a specification of which atoms are urelements, a singleton function exists, (...) unique up to isomorphism. (This article is partly abridged from my Parts of Classes, partly a sequel.). (shrink)

This is the second volume of philosophical essays by one of the most innovative and influential philosophers now writing in English. Containing thirteen papers in all, the book includes both new essays and previously published papers, some of them with extensive new postscripts reflecting Lewis's current thinking. The papers in Volume II focus on causation and several other closely related topics, including counterfactual and indicative conditionals, the direction of time, subjective and objective probability, causation, explanation, perception, free will, and rational (...) decision. Throughout, Lewis analyzes global features of the world in such a way as to show that they might turn out to supervene on the spatiotemporal arrangement of local qualities. (shrink)

Refutes the methodological separatists who hold that the logic of explanation and testing in the human sciences is fundamentally different than in the natural sciences, and develops complementary accounts for interpretation and explanation, ...

In Empirical Realism David K. Clark asks, simply: is there a moral structure to the universe?

In codifying the methods of translation, several writers have formulated maxims that would constrain interpreters to construe their subjects as (more or less) rational speakers of the truth. Such maxims have come to be known as versions of the principle of charity. W. V. O. Quine suggests an empirical, not purely methodological, basis for his version of that principle. Recently, Stephen Stich has criticized Quine's attempt to found the principle of charity in translation on information about the probabilities of various (...) sorts of mistakes. Here 1 defend Quine's approach. These issues have important implications for the supposed a priori status of human rationality. (shrink)

I argue that the moral distinction in double effect cases rests on a difference not in intention as traditionally stated in the Doctrine of Double Effect (DDE), but in desire. The traditional DDE has difficulty ensuring that an agent intends the bad effect just in those cases where what he does is morally objectionable. I show firstly that the mental state of a rational agent who is certain that a side-effect will occur satisfies Bratman's criteria for intending that effect. I (...) then clarify the nature of the moral distinction in double effect cases and how it can be used to evaluate the moral blameworthiness of agents rather than the moral status of acts. The agent's blameworthiness is reduced not by his lack of intention but by his desire not to bring about the side-effect, and the 'counterfactual test' can be used to determine whether he desires the effect in acting. In my version, the DDE has its rationale in virtue ethics; it is not liable to abuse as the traditional version is; and it makes more plausible distinctions when applied to standard examples. (shrink)

This article investigates and provides guidelines to the negative impact of mahadi on the Basotho youth before they may marry. It is important to note that marriage is one of the main parts of the life cycle amongst the Basotho and not only joins a man and a woman together, but is also considered to unite the members of the respective families of the married couple into one family. This union of two families comes into effect when the process of (...) negotiation of the mahadi is initiated. The negotiation for mahadi is, in other words, the first stage of bonding two families together. In the hope of gaining a better understanding and results, the writer searched for a qualitative method to conduct the research. (shrink)

This article investigates the practice of vat en sit to offer solutions to church councils of the mainly Black Reformed Churches in South Africa and also to the couples and families involved in such a relationship. Vat en sit is fast becoming a common phenomenon in South Africa. It should be noted that some of the couples in the vat-en-sit relationships may enter into it with no formal agreement. However, there are partners who may enter into this kind of relationship (...) through a universal partnership agreement whereby the couple plan to live together without marrying one another or a domestic life-partnership agreement whereby the couple opt to regulate their rights and duties in a vat-en-sit relationship. It does not, however, affect only the black members of the Reformed Churches in South Africa but also the family structures of society. The article thus endeavours to determine the reasons why many couples go this route and also how church councils could be assisted in dealing with the issue of vat en sit. This concept will be disseminated under the following headings: The causes of vat en sit relationships Implications of vat en sit The effect of a vat-en-sit relationship in the church The solution to the issue of vat en sit is to assist church councils, couples and their immediate and extended families. (shrink)